A scientist notices that a cancer cell line fails to die when they add an inducer of apoptosis to his culture of cells. Which hypothesis could explain why the cells fail to die?

The cells have a mutation that prevents the initiation of apoptosis signaling.
The cells have lost expression of the receptor for the apoptosis - inducing ligand.
The cells overexpress a growth factor pathway that inhibits apoptosis.
All of the above.

Question

A scientist notices that a cancer cell line fails to die when they add an inducer of apoptosis to his culture of cells. Which hypothesis could explain why the cells fail to die?

The cells have a mutation that prevents the initiation of apoptosis signaling.
The cells have lost expression of the receptor for the apoptosis - inducing ligand.
The cells overexpress a growth factor pathway that inhibits apoptosis.
All of the above.

Accepted Answer

***D*** ∻Key Concept∻ ⚹Apoptosis resistance in cancer cells⚹ ∻Explanation∻ ⚹Cancer cells can develop resistance to apoptosis through various mechanisms, including mutations that prevent apoptosis signaling, loss of receptor expression for apoptosis-inducing ligands, and overexpression of growth factor pathways that inhibit apoptosis.⚹◊What molecular pathways are involved in the process of apoptosis⍭ Generate me a similar question◊

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