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Question
Biology
Posted 7 months ago
Discuss the modern drug discovery process and how it has facilitated the
throughput of drug discovery.
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Answer from Sia
Posted 7 months ago
Answer
The modern drug discovery process has significantly improved the efficiency and throughput of discovering new drugs.
Solution
a
Target Identification: This step involves identifying the biological target, such as a protein or gene, that is associated with a disease
b
Hit Identification: High-throughput screening (HTS) is used to test thousands of compounds to find potential "hits" that interact with the target
c
Lead Optimization: The hits are further refined to improve their efficacy, selectivity, and pharmacokinetic properties
d
Preclinical Testing: Optimized leads undergo in vitro and in vivo testing to assess their safety and efficacy before moving to clinical trials
Key Concept
High-throughput screening (HTS)
Explanation
HTS allows for the rapid testing of thousands of compounds, significantly speeding up the initial stages of drug discovery.

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