Explain how a reference interval is determined

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Accepted Answer

∻Answer∻ ⚹ A reference interval is determined through the collection and statistical analysis of test results from a reference population. ⚹ ∻Solution∻ ‖ a ⋮ Selection of a reference population: A group of individuals who are similar in characteristics such as age, sex, and health status is chosen. ‖ ‖ b ⋮ Collection of data: Blood samples or other specimens are collected from the reference population and analyzed to obtain test results. ‖ ‖ c ⋮ Statistical analysis: The test results are subjected to statistical analysis to determine the central 95% of values, which typically defines the reference interval. This involves calculating the 2.5th percentile and the 97.5th percentile values. ‖ ‖ d ⋮ Validation and review: The reference interval is then validated and reviewed periodically to ensure its accuracy and relevance. ‖ ∻Key Concept∻ ⚹ Reference interval determination ⚹ ∻Explanation∻ ⚹ It involves selecting a reference population, collecting data, performing statistical analysis, and validating the interval.◊How does variability in biological parameters affect the determination of reference intervals?⍭ Generate me a similar question◊⚹

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