In the classical pathway of complement system activation, the cascade of reactions is activated when a specific complement system protein attaches to

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∻Answer∻ ⚹ The classical pathway of complement system activation is initiated when a specific complement protein, C1, attaches to an antibody that is bound to a pathogen. ⚹ ∻Solution∻ ‖ a ⋮ Initial Recognition: The classical pathway is triggered when the C1 complex (C1q, C1r, C1s) binds to the Fc region of antibodies (IgG or IgM) that are attached to antigens on the surface of a pathogen. ‖ ‖ b ⋮ Activation of C1: The binding of C1q to the antibodies activates the serine proteases C1r and C1s within the C1 complex. ‖ ‖ c ⋮ Cascade of Reactions: Activated C1s cleaves and activates the next complement proteins in the cascade, C4 and C2, forming the C4b2a complex, also known as the C3 convertase. ‖ ‖ d ⋮ Amplification and Outcome: The C3 convertase cleaves C3 into C3a and C3b, leading to opsonization of pathogens, recruitment of inflammatory cells, and formation of the membrane attack complex (MAC) that can lyse pathogens. ‖ ∻Key Concept∻ ⚹ Classical pathway activation in the complement system ⚹ ∻Explanation∻ ⚹ The classical pathway is activated by the binding of the C1 complex to antibodies attached to a pathogen, leading to a cascade of reactions that enhance the immune response. ⚹◊How does the attachment of C1 complex lead to the activation of the classical pathway of complement system activation?⍭ Generate me a similar question◊

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