Malonate $\mathrm{COOH}-\mathrm{CH} 2$ - $\mathrm{COOH}$ is a reversible competitive enzyme inhibitor that blocks this cycle. Which step does it inhibit?

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Accepted Answer

∻Answer∻ ⚹ Malonate inhibits the enzyme succinate dehydrogenase in the citric acid cycle. ⚹ ∻Solution∻ ‖ a ⋮ Identification of the cycle: Malonate is known to inhibit a specific enzyme in the citric acid cycle, also known as the Krebs cycle or tricarboxylic acid (TCA) cycle. ‖ ‖ b ⋮ Target enzyme: The enzyme that malonate inhibits is succinate dehydrogenase. This enzyme catalyzes the oxidation of succinate to fumarate. ‖ ‖ c ⋮ Mechanism of inhibition: Malonate is a competitive inhibitor, which means it competes with the substrate (succinate) for the active site of the enzyme succinate dehydrogenase. ‖ ∻Key Concept∻ ⚹ Competitive inhibition of enzymes ⚹ ∻Explanation∻ ⚹ Malonate resembles the structure of succinate and competes with it for binding to the active site of succinate dehydrogenase, thereby inhibiting the conversion of succinate to fumarate in the citric acid cycle. ⚹◊What is the specific enzyme that malonate inhibits in the cycle mentioned?⍭ Generate me a similar question◊

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