Phosphofructokinase is inhibited by acid. Which is the best metabolic reason for this?

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Accepted Answer

∻Answer∻ ⚹ Phosphofructokinase is inhibited by acid as a regulatory mechanism to prevent excessive glycolysis and subsequent lactate accumulation under low pH conditions. ⚹ ∻Solution∻ ‖ a ⋮ Feedback inhibition ⋮ Phosphofructokinase (PFK) is subject to feedback inhibition by hydrogen ions (H⁺), which accumulate when muscle cells undergo anaerobic respiration and produce lactic acid. ‖ ‖ b ⋮ Protection of cellular pH ⋮ By inhibiting PFK, the cell prevents further acid production from glycolysis, thus protecting the cell from detrimental low pH levels that can denature proteins and interfere with other metabolic processes. ‖ ‖ c ⋮ Energy conservation ⋮ Inhibition of PFK under acidic conditions prevents the unnecessary expenditure of ATP in glycolysis, conserving energy for when conditions are more favorable for ATP production. ‖ ∻Key Concept∻ ⚹ Metabolic regulation of PFK by pH ⚹ ∻Explanation∻ ⚹ The inhibition of phosphofructokinase by acid is a metabolic control mechanism that helps maintain cellular homeostasis by preventing excessive acidification and conserving energy. ⚹◊How does acid inhibit the activity of phosphofructokinase in glycolysis?⍭ Generate me a similar question◊

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