Skeletal muscle is an important store of glycogen in the body.a) Describe the sequence of events that occur from the binding of adrenaline to the beta - adrenergic receptor to the activation of cAMP dependent protein kinase in skeletal muscle cells. (12 marks)

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∻Answer∻ ⚹ The sequence of events from the binding of adrenaline to the beta-adrenergic receptor to the activation of cAMP-dependent protein kinase involves multiple steps leading to the conversion of glycogen to glucose in skeletal muscle cells. ⚹ ∻Solution∻ ‖ a ⋮ Adrenaline binds to the beta-adrenergic receptor on the skeletal muscle cell membrane. ‖ ‖ b ⋮ This binding causes a conformational change in the receptor that activates the G protein associated with it. ‖ ‖ c ⋮ The activated G protein then activates adenylate cyclase, an enzyme on the inner side of the cell membrane. ‖ ‖ d ⋮ Adenylate cyclase converts ATP to cyclic AMP (cAMP). ‖ ‖ e ⋮ cAMP acts as a secondary messenger and binds to the regulatory subunits of cAMP-dependent protein kinase (PKA), causing a conformational change that releases the catalytic subunits. ‖ ‖ f ⋮ The free catalytic subunits of PKA then phosphorylate specific proteins, leading to the activation of glycogen phosphorylase, the enzyme responsible for glycogen breakdown. ‖ ∻Key Concept∻ ⚹ The key concept is the signal transduction pathway that leads to the activation of cAMP-dependent protein kinase (PKA) in skeletal muscle cells in response to adrenaline. ⚹ ∻Explanation∻ ⚹ This process is an example of a cascade of events where a hormone (adrenaline) triggers a series of biochemical reactions inside the cell, resulting in a physiological response (glycogen breakdown). The process amplifies the signal at each step, leading to a significant cellular response from a small initial signal. ⚹◊What role does cAMP dependent protein kinase play in the regulation of glycogen metabolism in skeletal muscle cells?⍭ Generate me a similar question◊

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