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Posted 3 months ago
What allows the RNA polymerase holoenzyme to recognize the promoter and bind to it, but is not found in the core polymerase in E. coli?
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Answer from Sia
Posted 3 months ago
The RNA polymerase holoenzyme recognizes the promoter and binds to it due to the presence of the sigma factor, which is not found in the core polymerase.
Sigma factor: The sigma factor is a protein that associates with the core RNA polymerase to form the holoenzyme
Promoter recognition: The sigma factor is responsible for recognizing the specific promoter sequences in the DNA, allowing the holoenzyme to bind specifically to promoters
Key Concept
Sigma factor in RNA polymerase holoenzyme
The sigma factor is crucial for the initiation of transcription in E. coli as it enables the RNA polymerase holoenzyme to recognize and bind to promoter sequences.

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