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Question
Biology
Posted 8 months ago
What is the function of the 3 'à5' exonuclease domain in DNA polymerase?
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Answer from Sia
Posted 8 months ago
Answer
The 3' to 5' exonuclease domain in DNA polymerase is responsible for proofreading the newly synthesized DNA strand and correcting errors by removing mismatched nucleotides.
Solution
a
Error Correction: The 3' to 5' exonuclease activity checks the newly added nucleotide against the template strand. If a mismatch is detected, it removes the incorrect nucleotide
b
DNA Integrity: This proofreading function is crucial for maintaining the integrity of the DNA and preventing mutations
Key Concept
Proofreading by DNA polymerase
Explanation
The 3' to 5' exonuclease domain of DNA polymerase ensures the accuracy of DNA replication by removing incorrectly paired nucleotides.
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