Which of the following mutations in a gene encoding a transmembrane receptor protein is most likely to create an allele that is completely dominant to a wild type allele?

Group of answer choices

A deletion of the entire coding region.

A deletion of the binding site for a transcription factor that activates expression of the gene.

A missense mutation causing the receptor to be active in the absence of ligands that would normally be needed to activate it.

A missense mutation reducing the signaling capabilities of the receptor.

Question

Which of the following mutations in a gene encoding a transmembrane receptor protein is most likely to create an allele that is completely dominant to a wild type allele?

Group of answer choices

A deletion of the entire coding region.

A deletion of the binding site for a transcription factor that activates expression of the gene.

A missense mutation causing the receptor to be active in the absence of ligands that would normally be needed to activate it.

A missense mutation reducing the signaling capabilities of the receptor.

Accepted Answer

***C*** ∻Key Concept∻ ⚹Constitutive Activity⚹ ∻Explanation∻ ⚹A missense mutation causing the receptor to be active in the absence of ligands would result in a gain-of-function mutation, making the allele completely dominant to the wild type. This is because the receptor is constitutively active, meaning it signals continuously without the need for its normal activating ligand.⚹◊What is the potential impact of a missense mutation causing a receptor to be active in the absence of ligands that would normally be needed to activate it on the dominance of the allele?⍭ Generate me a similar question◊

Sia