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Posted 3 months ago
the link between cholera and diarrhea with membrane biology in mind
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Answer from Sia
Posted 3 months ago
Cholera causes diarrhea through the disruption of ion transport in the intestinal membrane.
Cholera toxin (CT) : The bacterium Vibrio cholerae produces CT, which binds to the intestinal epithelial cells
cAMP levels : CT activates adenylate cyclase, causing an increase in intracellular cAMP
Ion transport disruption : Elevated cAMP stimulates the secretion of Cl⁻ ions into the intestinal lumen and inhibits Na⁺ absorption
Water efflux : The osmotic gradient created by Cl⁻ secretion draws water into the lumen, causing diarrhea
Key Concept
Cholera toxin's effect on ion transport
Cholera toxin leads to increased cAMP in intestinal cells, disrupting ion transport and causing water to flow into the intestinal lumen, resulting in diarrhea.

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