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Question
Biology
Posted 3 months ago
If there was a single base insertion, so the above sequence changed from
5' - UUUAUGUGAAACCAUGGUUAAGGCCUAGACUACCAAAAAAAAAAAA-3' to
5' - UUUAUGUGAAACCAUGG AUUAAGGCCUAGACUACCAAAAAAAAAAAA-3'
What amino acids would the new sequence encode?
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Answer from Sia
Posted 3 months ago
Answer
The new sequence would encode a different set of amino acids due to a frameshift mutation caused by the single base insertion.
Solution
a
Identify the point of insertion: The single base insertion occurs after the eighth codon in the sequence
b
Determine the original codons before insertion: The original sequence has the codons 5' - UUU AUG UGA AAC CAU GGU UAA GG - 3' before the insertion point
c
Translate the original codons to amino acids: The original codons encode the amino acids Phenylalanine (UUU), Methionine (AUG, start codon), Stop (UGA), Asparagine (AAC), Histidine (CAU), Glycine (GGU), Stop (UAA)
d
Determine the new codons after insertion: The new sequence with the insertion (denoted by a space) has the codons 5' - UUU AUG UGA AAC CAU GGU AUA AGG CCU AGA CU - 3' after the insertion point
e
Translate the new codons to amino acids: The new codons encode the amino acids Phenylalanine (UUU), Methionine (AUG), Stop (UGA), Asparagine (AAC), Histidine (CAU), Glycine (GGU), Isoleucine (AUA), Arginine (AGG), Proline (CCU), Arginine (AGA), and the sequence is likely truncated due to the stop codon
Key Concept
Frameshift mutation
Explanation
A single base insertion can cause a frameshift mutation, altering the reading frame of the genetic code and potentially changing every amino acid encoded after the point of insertion. This can lead to a completely different protein being produced, or to a nonfunctional protein if a premature stop codon is introduced.

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