Which of the following compounds is the most reactive in a nucleophilic substitution reaction

CH3CONH2 ACETAMIDE
$\mathrm{CH} 3 \mathrm{COO}$ - ACETATE ION
$\mathrm{CH} 3 \mathrm{COCl}$ - acetyl chloride
$\mathrm{CH} 3 \mathrm{COOCOCH3}$ ACETIC ANHYDRIDE
$\mathrm{CH} 3 \mathrm{COOCH} 3$ ESTER

Question

Which of the following compounds is the most reactive in a nucleophilic substitution reaction

CH3CONH2 ACETAMIDE
$\mathrm{CH} 3 \mathrm{COO}$ - ACETATE ION
$\mathrm{CH} 3 \mathrm{COCl}$ - acetyl chloride
$\mathrm{CH} 3 \mathrm{COOCOCH3}$ ACETIC ANHYDRIDE
$\mathrm{CH} 3 \mathrm{COOCH} 3$ ESTER

Accepted Answer

***C*** ∻Key Concept∻ ⚹Reactivity in nucleophilic substitution⚹ ∻Explanation∻ ⚹Acetyl chloride ($\mathrm{CH_3COCl}$) is the most reactive in a nucleophilic substitution reaction due to the good leaving group (Cl-) and the partial positive charge on the carbonyl carbon, making it highly susceptible to attack by nucleophiles.⚹◊Which functional group is most reactive in a nucleophilic substitution reaction⍭ Generate me a similar question◊

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