Define and contrast the roles of initiator caspases and executioner caspases

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∻Answer∻ ⚹ Initiator caspases activate executioner caspases, which then carry out apoptosis by cleaving specific cellular substrates. ⚹ ∻Solution∻ ‖ a ⋮ Initiator caspases: These are responsible for the early stages of the apoptosis signaling pathways. They are activated by apoptotic signals and subsequently activate executioner caspases. ‖ ‖ b ⋮ Executioner caspases: Once activated by initiator caspases, they cleave various cellular proteins to trigger the morphological and biochemical changes associated with apoptosis. ‖ ∻Key Concept∻ ⚹ The distinction between initiator and executioner caspases lies in their roles in the apoptosis cascade. ⚹ ∻Explanation∻ ⚹ Initiator caspases begin the apoptosis process by activating executioner caspases, which then dismantle the cell. ⚹◊How do initiator caspases activate executioner caspases in apoptosis?⍭ Generate me a similar question◊

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